Database : HANSEN Search on : ANTIGENOS DE BACTERIAS [Subject descriptor] References found : 187 [refine] Displaying: 1 .. 20   in format [Detailed]

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Id: 19590 Author: Lord, Rosanne; Naish, Caroline; Taylor, Clare; Stanford, Cynthia; Stanford, John L; Chacko, Chinoy JG; Debandu, Vivanathan; Samson, Prabhakar D; Berchmans, John; Surendran, Deeradaylu; Ramu, Gopal; Rees, Richard JW. Title: Skin test studies on close contacts of leprosy patients in India. Source: Int. J. Lep;57(4):801-809, dec. 1989. ^btab, ^bgraf. Abstract: Skin-test studies with a series of tuberculins have been carried out in close contacts of multibacillary (MB) leprosy patients around three leprosy centers in India, and casual contacts of the disease around two centers. The results show that the rate of acquisition of leprosin A positivity is associated with age and the closeness of contact with MB leprosy. At the age of 15 years, the differences between the two types of contact were highly significant (p less than 0.00001). Many responses to leprosin A are directed toward the group iv species-specific, antigens of the leprosy bacillus, and the significance of positivity is discussed in relation to protective immunity from leprosy. The differences from Iran show that positivity to leprosin A is not solely the effect of the degree of contact with the disease, but must also have a genetic or environmental element, the latter being favored. The results from Miraj show that the high levels of tuberculin, scrofulin, and vaccin positivity seen in Fathimanagar, and to a lesser extent in Karigiri, are not a consequence of contact with leprosy. BCG vaccination made little difference to the leprosin A positivity of close contacts of leprosy patients, although it significantly enhanced positivity among casual contacts around Miraj (p less than 0.002). BCG vaccination significantly increased tuberculin positivity in Miraj and Karigri, and in those under 11 years of age in Fathimanagar. It made no difference to the already high level of positivity found in older persons around Fathimanagar. Descriptors: Antígenos de Bactérias/imunol Vacina BCG/imunol Hanseníase/epidemiol Hanseníase/transm Índia/epidemiol Limits: Humanos Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n4/v57n4a08.pdf / en Location: Br191.1

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Id: 19588 Author: Mutis, Tuna; Van Schoote, Wim CA; Vries, René RP. Title: A peptidoglycan protein complex purified from M Leprae cell walls contains most or all immunodominat M leprae T-cell antigens. Source: Int. J. Lep;57(4):788-793, dec. 1989. . Abstract: The outcome of an infection with Mycobacterium leprae is correlated with the T-cell-mediated immune response developed against this pathogenic agent. The identification of M. leprae antigens that are recognized by T cells is therefore of great importance. In this paper we present the results of in vitro lymphoproliferation assays in which T-cell reactivity was measured against a peptidoglycan-protein complex (PPC) which was purified from the cell wall of M. leprae. Twelve M. leprae-reactive T-cell clones with different antigen specificities from a tuberculoid (TT) leprosy patient showed proliferative responses, but only when PPC was presented by HLA-DR-matched antigen-presenting cells (APCs). Four of these clones were known to react with the recombinant mycobacterial 65-kDa protein. A tetanus-toxoid-reactive T-cell line from a healthy control was not stimulated by this complex, supporting the idea that the stimulation by PPC was antigen specific. Both PPD-reactive and M. leprae-reactive T-cell lines from healthy individuals were stimulated by PPC. However, when this complex was presented to PPD-reactive T-cell lines derived from two lepromatous (LL) leprosy patients, we did not observe any proliferative responses. From these results we conclude that PPC contains most or all of the antigens which stimulate M. leprae-reactive T cells in association with relevant HLA class II molecules, including the 65-kDa protein or at least some immunogenic parts of it. Descriptors: Antígenos de Bactérias/imunol Parede Celular/fisiol Mycobacterium leprae/imunol Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n4/v57n4a06.pdf / en Location: Br191.1

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Id: 19587 Author: Mullins, raymond J; Basten, Antony. Title: Effect pf preincubation on the proliferative response to antigen by cells from leprosy patients and healthy controls. Source: Int. J. Lep;57(4):777-787, dec. 1989. ^btab, ^bgraf. Abstract: One of the postulated mechanisms contributing to the selective T-cell hyporesponsiveness in patients with leprosy is receptor blockade, the characteristic feature of which is reversibility following preincubation of cells in vitro. To test this hypothesis, peripheral blood mononuclear cells (PBMC) obtained from 17 leprosy patients and 10 healthy Mantoux-positive and -negative controls were cultured freshly or after a period of preincubation in serum-containing medium, and the proliferative responses to Mycobacterium leprae, BCG, and streptokinase-streptodornase (SKSD) were measured. On the basis of the response to M. leprae, the leprosy patients could be divided into low, intermediate and high responders. Preincubation for 2-16 hr resulted in enhanced proliferation by cells from moderate responders, but not from low or high responders. Although the effect was serum dependent, it was neither antigen specific nor was it confined to cells from leprosy patients. Thus, an increase in response to both the crossreactive and unrelated antigens BCG and SKSD occurred, and the same trend was observed when cells from healthy controls were preincubated in serum-containing medium. Furthermore, cells from different individuals displayed varying responses to different antigens following preincubation, suggesting that the effect of this step was neither confined to isolated individuals nor to particular antigens. The addition of pronase to the preincubation step did not further enhance the response to antigen over and above that obtained with preincubation alone. It was therefore concluded that the enhanced proliferative response to antigen following preincubation was an in vitro phenomenon dependent upon the culture conditions employed, was not specific to leprosy, and was not related to receptor blockade. Descriptors: Antígenos de Bactérias/imunol Fenômenos Fisiológicos Sanguíneos Mycobacterium bovis/imunol Mycobacterium leprae/imunol Limits: Humanos Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n4/v57n4a05.pdf / en Location: Br191.1

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Id: 19584 Author: Gelber, Robert H; Li, Futian; Cho, SN; Byrd, Sally; Rajagopalan, K; Brennan, Patrick J. Title: Serum antibodies to defined carbohydrate antigens during the course of treated leprosy. Source: Int. J. Lep;57(4):744-751, dec. 1989. . Abstract: Sequential monitoring of 724 sera for antibodies to a neoantigen based on phenolic glycolipid-I (PGL-I) and native lipoarabinomannan (LAM) in 90 leprosy patients undergoing therapy in San Francisco was conducted. Untreated lepromatous patients frequently (91%) had significant antibodies to both moieties. Antibodies were less frequently found in tuberculoid patients (74% to neoantigen and 37% to LAM). In the first 3 years of treatment, average serum antibodies to both moieties fell significantly. Antibodies to LAM fell during each of the first 4 years of therapy, but decreasing antibody levels to the PGL-I neoantigen did not appear to fall consistently after the third year of treatment. A wide variation in the rate of fall of serum antibodies was noted. Sequential changes in the amounts of serum antibodies to the neoantigen and LAM in general paralleled one another but were at times discrepant. Both in San Francisco and Malaysia, skin-smear negative, long-term treated, lepromatous leprosy patients frequently harbored significant antibodies to both PGL-I and LAM. Descriptors: Anticorpos Antibacterianos/imunol Anticorpos Antibacterianos/fisiol Antígenos de Bactérias/imunol Glicolipídeos/imunol Hanseníase/terap Limits: Humanos Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n4/v57n4a02.pdf / en Location: Br191.1

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Id: 19583 Author: Chanteau, Suzanne; Cartel, Jean-Louis; Celerier, Philippe; Plichart, Régis; Desforges, Sylvie; Roux, Jean. Title: PGL-1 antigen and antibody detection in leprosy patients: evolution under chemotherapy. Source: Int. J. Lep;57(4):735-743, dec. 1989. ^btab. Abstract: Multibacillary (MB) and paucibacillary (PB) leprosy patients were tested for circulating phenolic glycolipid-I (PGL-I) antigen and antibodies before treatment. In the 27 MB patients tested, 27 (100%) were antigen positive with levels ranging from 50 to 5000 ng/ml, and 26 (96%) were antibody positive with titers ranging from 1000 to 64,000. Although the antigen and antibody levels were much higher in MB than in PB patients, we could not demonstrate a correlation between the number of acid-fast bacilli/mg of skin biopsy and these two parameters in 14 MB patients. After starting daily multidrug therapy, 10 MB patients were monitored monthly. As much as 88.75% +/- 10.8% of the PGL-I antigen was cleared from the bloodstream after 1 month while the anti-PGL-I antibody remained stable. This rapid decrease in the PGL-I antigen level strongly suggests the usefulness of this test for monitoring MB patients under chemotherapy. Descriptors: Anticorpos Antibacterianos/anal Antígenos de Bactérias/anal Dapsona/uso terap Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n4/v57n4a01.pdf / en Location: Br191.1

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Id: 13942 Author: Maeda, Yumi; Gidoh, Masaichi; Ishii, Norihisa; Mukai, Chifumi; Makino, Masahiko Title: Assessment of cell mediated immunogenicity of Mycobacterium leprae-derived antigens ..- Source: s.l; s.n; 2003. 9 p. tab, graf. Abstract: The antigenicity of Mycobacterium leprae (M. leprae)-derived cell membrane fraction was examined using human dendritic cells (DCs). Immature DCs internalized and processed the cell membrane components, and expressed M. leprae-derived antigens (Ags) on their surface. The expression of MHC class II, CD86, and CD83 Ags on DCs and CD40 ligand (L)-associated IL-12 p70 production from DCs were up-regulated by the membrane Ags. Moreover these stimulated DCs induced significantly higher level of interferon-gamma (IFN-gamma) production by autologous CD4(+) and CD8(+) T cells than those pulsed with equivalent doses of live M. leprae or its cytosol fraction. Both subsets of T cells from tuberculoid leprosy patients also produced several fold more IFN-gamma than those from normal individuals. Furthermore, the intracellular perforin production in CD8(+) T cells was up-regulated in an Ag-dose dependent manner. These results suggest that M. leprae membrane Ags might be useful as the vaccinating agents against leprosy. (AU). Descriptors: ANTIGENOS DE BACTERIAS/imunol ANTIGENOS DE SUPERFÍCIE/imunol LINFOCITOS T CD4-POSITIVOS/imunol LIGANTE A CD40/fisiol LINFOCITOS T CD8-POSITIVOS/imunol CELULAS DENDRITICAS/imunol INTERFERON TIPO II/bios INTERLEUCINA-12/bios TRANSFORMACAO LINFOCITICA GLICOPROTEINAS DE MEMBRANA/bios MYCOBACTERIUM LEPRAE/imunol Limits: HUMANO SUPPORT, NON-U.S. GOV'T SUPPORT, U.S. GOV'T, P.H.S. Electronic Medium: http://www.ilsl.br Location: BR191.1; 09083/s

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Id: 13935 Author: Jayapal, V; Selvibai, G; Mahalakshmi, K; Pushkala; Regunath, K; Subramanian, S Title: Comparative study of anti-PGL-1, anti-35 kDa and anti-lipoarabinomannan assays for serodiagnosis of leprosy ..- Source: s.l; s.n; 2001. 9 p. tab. Abstract: Three antibody assays (anti-PGL-1, anti-35 kDa and anti-LAM) were used to determine the levels of antibodies in the sera of untreated leprosy patients. All the three assays showed higher levels of antibodies in BL/LL patients as compared to I and TT/BT patients, as well as healthy controls. BL/LL patients showed positivity of 100 per cent, 84.2 per cent and 78.9 per cent by anti-PGL-1, anti-35 kDa and anti-LAM assays respectively. All the three assays were negative for leprosy in healthy controls. Anti-PGL-1 assay was positive in 20 per cent of TT/BT patients and 17.9 per cent of I patients. Anti-35 kDa assay was negative in all the TT/BT patients and positive in 7.14 per cent of I patients. Anti-LAM assay was positive in 13.3 per cent of TT/BT patients and in 10.7 per cent of I patients. Hence, while these assays are valuable in diagnosing BL/LL patients, their usefulness in diagnosing I, BT or TT leprosy is limited. (AU). Descriptors: MYCOBACTERIUM LEPRAE/imunol TESTES SOROLOGICOS ANTICORPOS ANTIBACTERIAS/sangue ANTIGENOS DE BACTERIAS/imunol GLICOLIPIDIOS/imunol HANSENIASE/sangue HANSENIASE/clas HANSENIASE/diag HANSENIASE/imunol LIPOPOLISSACARIDIOS/imunol Limits: ESTUDO COMPARATIVO HUMANO MASCULINO FEMININO ADULTO MEIA-IDADE ADOLESCENTE Electronic Medium: http://www.ilsl.br Location: BR191.1; 09162/s

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Id: 13666 Author: Bala, Lakshmi; Anand, Sukumar; Sinha, Sudhir Title: Enhancement of human T cell response to a peptide epitope of 38kDa antigen of Mycobacterium tuberculosis by liposomes ..- Source: s.l; s.n; 2002. 9 p. graf. Abstract: Diagnosis of tuberculosis a problem, specially in the regions harboring an abundance of both pathogenic and non-pathogenic mycobacteria. This study was undertaken to assess in such a situation the predictive value of proliferative T cell response to a peptide epitope ('38G') of the 38 kDa membrane protein of Mycobacterium tuberculosis. 3[H]-thymidine incorporation assays were done with peripheral blood mononuclear cells of tuberculoid leprosy and pulmonary tuberculosis patients. The donors were also classified as PPD responders (Stimulation Index, SI> 3) or non-responders (SI < or = 3) on the basis of their T cell response to the 'Purified Protein Derivative (PPD)' of M. tuberculosis. 38G peptide was used in either free or liposome-associated form prepared by the technique of 'Dehydration-rehydration Vesicles' (Kirby and Gregoriadis, 1984). While free peptide failed to induce a positive response in study subjects, its liposomal form was T cell stimulatory and distinguished, to certain extent, between PPD responders (corresponding SI > 3 in 54 per cent subjects) and non-responders (SI > 3 in 29 per cent subjects). However, it did not differentiate between leprosy and tuberculosis. The study supports use of liposomes as adjuvant vehicles for antigenic peptides designed to activate human T cells. (AU). Descriptors: ANTIGENOS DE BACTERIAS/admin ANTIGENOS DE BACTERIAS/quim ANTIGENOS DE BACTERIAS/genet HANSENIASE TUBERCULOIDE/diag HANSENIASE TUBERCULOIDE/imunol EPITOPOS/admin EPITOPOS/quim EPITOPOS/genet DIAGNOSTICO DIFERENCIAL MYCOBACTERIUM TUBERCULOSIS/quim MYCOBACTERIUM TUBERCULOSIS/genet MYCOBACTERIUM TUBERCULOSIS/imunol DADOS DE SEQUÊNCIA MOLECULAR SEQUÊNCIA DE AMINOACIDOS LINFOCITOS T/imunol TESTE TUBERCULINICO TUBERCULOSE PULMONAR/diag TUBERCULOSE PULMONAR/imunol TRANSFORMACAO LINFOCITICA - LIPOSSOMOS  PESO MOLECULAR Limits: ESTUDO COMPARATIVO HUMANO IN VITRO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 09061/s

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Id: 13577 Author: Mehra, Vijay; Convit, Jacinto; Rubinstein, Arye; Bloom, Barry R Title: Activated suppressor T cells in leprosy ..- Source: s.l; s.n; nov. 1982. 6 p. tab, graf. Abstract: Leprosy is a spectral disease in which the patients at the lepromatous end display selective immunologic unresponsiveness to antigens of M. leprae. We have previously explored the possibility that the anergy in lepromatous leprosy mediated by suppressor cells. An in vitro system was developed in which lepromin induces suppression of the mitogenic response of lepromatous and borderline but not tuberculoid leprosy patients to concavalin A.(AU). Descriptors: HANSENIASE/imunol HANSENIASE/terap LINFOCITOS T SUPRESSORES-EFETORES/imunol ANTIGENOS DE BACTERIAS/admin ANTIGENOS DE HISTOCOMPATIBILIDADE CLASSE II/imunol ANTIGENO DE MITSUDA/imunol RECEPTORES FC/genet IMUNOTERAPIA Limits: HUMANO SUPPORT, NON-U.S. GOV'T SUPPORT, U.S. GOV'T, P.H.S. Electronic Medium: http://www.ilsl.br Location: BR191.1; 01419/s

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Id: 13560 Author: Purtilo, David T; Walsh, Gerald P; Storrs, Eleanor E; Banks, Isaac S Title: Impact of cool temperatures on transformation of human and armadilio lymphocytes ( Dasypus novemcinctus, Linn. ) as related to leprosy ..- Source: s.l; s.n; March 29, 1974. 3 p. tab, graf. Abstract: A CENTURY-LONG search for an unaltered animal in which to study leprosy in humans culminated in the finding that the nine-banded armadillo (Dasypus novemcinctus, Linn.) a primitive mammal native to the southern Western Hemisphere, develops disseminated lepromstous leprosy following inocuation with Mycobacterium leprae isolated from human tissue.(AU). Descriptors: TRANSFORMACAO LINFOCITICA/ef drogas MYCOBACTERIUM LEPRAE/imunol XENARTROS/imunol HANSENIASE/imunol LECTINAS MODELOS ANIMAIS DE DOENCAS ANTIGENOS DE BACTERIAS FRIO Limits: HUMANO ANIMAL MASCULINO FEMININO Electronic Medium: http://www.ilsl.br Location: BR191.1; 00494/s

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Id: 13545 Author: Convit, Jacinto; Avila, J. L; Goihman, M; Pinardi, M. E Title: A test for the determination of competency in clearing bacilli in leprosy patients ..- Source: s.l; s.n; 1972. 6 p. ilus. Abstract: A skin test has been developed to determine the degree of competency in clearing bacilli from the tissues of patients suffering from various forms of leprosy. The test involves the intradermal ijection of a suspension of killed Mycobacterium leprae. The response of leprosy patients to the injection of other mycobacterial antigens, one prepared from M. lepraemurium and another from an atypical mycobacterium from a hamster, was also investigated in roder to study the isopathic phenomenon. Since lepromatous patients react negatively in tests with standard Mitsuda antigen, a concentration of 640 x 10(6) M. leprae per ml was used to producce macroscopic responses. The results of the test can be applied to determine the duration of consolidation treatment for lepromatous and indeterminate bacteriologically negative patients after regular treatment has ended. The test can also be used to indicate which Mitsuda-negative contacts should be given preventive treatment, and might be used to identify a given mycobacterium as M. leprae.(AU). Descriptors: ANTIGENOS DE BACTERIAS BIOPSIA HANSENIASE/imunol HANSENIASE/patol MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAEMURIUM PELE/patol TESTES CUTÂNEOS - MACROFAGOS  METODOS  FAGOCITOSE Limits: HUMANO Electronic Medium: http://www.ilsl.br Location: BR191.1; 00581/s

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Id: 13538 Author: Massalski, W; Kozminska-Kubarska, A; Shukla, Rama Raksha Title: Skin reactions to selected antigens in patients with leprosy ..- Source: s.l; s.n; 1982. 4 p. tab. Abstract: The purpose of the work was comparison of reactivity of patients with the lepromatous and the tuberculoid type of leprosy. To 15 patients with the lepromatous and to 20 patients the tuberculoid type several antigens were administered intradermally. The antigens were obtained from alcohol - and acidfast microorganisms isolated from:- skin changes of cases lepromatous type, - skin of a case with tuberculoid type, - skin of a healthy person.The reactions to standard lepromin served as a reference. No correlation was found between the clinical picture, bacteriological examination and reactions to standard lepromin. A high percentage of positive results, observed in the group of cases with lepromatous type, using the antigen prepared from a patient with tuberculoid leprosy is of particular interest. This phenomenon may depend on differences within HLA subgroups in patients with the lepromatous and the tuberculoid type of leprosy. (AU). Descriptors: HANSENIASE/imunol ANTIGENOS DE BACTERIAS/imunol TESTES CUTÂNEOS Limits: HUMANO MASCULINO FEMININO Location: BR191.1; 08985/s

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Id: 13497 Author: Ivanyi, J; Sinha, S; Aston, R; Cussell, D; Keen, M; Sengupta, U Title: Definition of species specific and cross-reactive antigenic determinants of Mycobacterium leprae using monoclonal antibodies ..- Source: s.l; s.n; jun. 1983. 9 p. ilus, tab. Abstract: Four soluble antigens of Mycobacterium leprae have been identified using 12 murine monoclonal antibodies. Their specificity, taxonomic distribution and molecular nature were analysed by radioimmunoassays and by immunoblotting from polyacrylamide electrophoresis gels. A protein antigen MY1 (12K) reacted with one antibody (ML06) without demonstrable cross-reactivity for any of the other 20 tested species of mycobacteria. Another four antibodies which identified antigen MY2 revealed only a marginal degree of cross-reactivity with three other species of mycobacteria. Two antigens shared by several other mycobacteria species were: MY3 represented by five protein bands (35-70K) and a subtilisin resistant molecule MY4 (40-50K) with two distinct determinants and presumably of polysaccharide nature. The described monoclonal antibodies may represent novel valuable diagnostic reagents as well as tools for the purification of antigens which could be explored towards prophylactic or therapeutic immunization against leprosy.(AU). Descriptors: MYCOBACTERIUM LEPRAE/imunol MYCOBACTERIUM/imunol ELETROFORESE EM GEL DE POLIACRILAMIDA EPITOPOS/anal EPITOPOS/imunol LIGACAO COMPETITIVA ANTIGENOS DE BACTERIAS/anal ANTIGENOS DE BACTERIAS/imunol ANTICORPOS MONOCLONAIS/imunol Limits: SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 01394/s

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Id: 13475 Author: Das, P. K; Ibrahim, A. A; Binkhuysen, F; Thi Hué, P; Qui, T. H; Rangarajan R;; Ruitenberg EJ Title: The use of subcellular components of BCG for studying host-Mycobacterium interaction in relation to leprosy ..- Source: s.l; s.n; Jul.-Aug. 1982. 19 p. ilus, tab, graf. Abstract: Mycobacterium bovis-BCG was sonified and centrifuged at 90,000g for 2h to obtain pellet (P90) and supernatant (S90), and bacilli broken by chilled X-press were fractionated into cell wall (CW), plasma membrane and cytosol. Rabbits were immunized with P90, S90 and whole sonified-broken BCG. The antigenic make-up of these antisera. These analysed by cross-immunoelectrophoresis using the antisera. These subcellular preparations were also used for detecting circulating antibodies in the sera of 45 leprosy patients by Ouchterlony´s technique and immunoelectrophoresis. Although there were many antigenic determinants common to more than one fraction, some components were found in only one fraction. Furthermore, different leprosy patients showed different patterns of antibody response to the antigens in the different fractions. In addition, these fractions were also used to assess cell-mediated immunity in mice sensitized with lyophilized whole BCG as well as with irradiated Mycobacterium. it was found that BCG, intraperitoneally injected, engedered different specifically antigen-sensitized populations of lymphocytes in the spleen and lymph node. Moreover, a certain degree of antigenic cross-reactivity was observed between BCG and M. leprae, possibly at the T-cell level. In vitro experiments suggested that the CW stimulated B cells, indicating a mitogenic ctivity leading to polyclonal activation. Finally, in vitro priming experiments established that these subcellular fractions could sensitize human peripheral lymphocytes, and upon secondary culture all primed cells were able to respond to homologous preparations but not always to heterologous preparations, thus offering a means to distinguish antigens of interest from those antigenically less complicated fractions at the T-cell level.(AU). Descriptors: MYCOBACTERIUM LEPRAE/imunol CAMUNDONGOS ENDOGÂMICOS CBA MYCOBACTERIUM BOVIS/imunol IMUNOELETROFORESE BIDIMENSIONAL HANSENIASE/imunol ANTICORPOS ANTIBACTERIAS/anal ANTIGENOS DE BACTERIAS/anal TATUS FRACOES SUBCELULARES/imunol Limits: HUMANO ANIMAL FEMININO CAMUNDONGOS COELHOS SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 01556/s

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Id: 13431 Author: Melsom, R; Duncan, M. E; Harboe, M; Bjune, G Title: Antibodies against Mycobacterium leprae antigen 7 from birth to 18 months of age: an indicator of intra-uterine infection in leprosy ..- Source: s.l; s.n; oct. 1980. 7 p. tab, graf. Abstract: All babies of three non-leprosy mothers and ten tuberculoid leprosy mothers and four of five babies of mothers with inactive lepromatous leprosy showed a decline in serum concentration of antibodies against M. leprae antigen 7 during the first 4 months of life, as expected from catabolism of maternal IgG. By contrast, ten of twenty babies of mothers with active lepromatous leprosy showed a decline in concentration of anti-M. leprae 7 antibodies considerably less than expected. This indicates that these babies have been stimulated by M. leprae antigen 7, either as free antigen or by viable M. leprae before birth, and thus that leprosy may occur as a congenital infection. Studies of anti-M. leprae antibodies in repeated serum samples obtained during the first 18 months of life indicated that children of mothers with bacilliferous leprosy are frequently exposed to M. leprae to a sufficient extent to stimulate the immune system of the baby to production of anti-M. leprae antibodies during this period. The consequences of this exposure to M. leprae should be ascertained by careful clinical studies.(AU). Descriptors: HANSENIASE/imunol TROCA MATERNO-FETAL MYCOBACTERIUM LEPRAE/imunol IMUNOGLOBULINA G/metab ENVELHECIMENTO SANGUE FETAL/imunol ANTIGENOS DE BACTERIAS/imunol ANTICORPOS ANTIBACTERIAS/anal Limits: HUMANO FEMININO GRAVIDEZ RECÉM-NASCIDO LACTENTE SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 00461/s

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Id: 13429 Author: Nogueira, N; Kaplan, G; Levy, E; Sarno, E. N; Kushner, P; Granelli-Piperno, A; Vieira, L; Colomer Gould, V; Levis, W; Steinman, R Title: Defective gamma interferon production in leprosy ..- Source: s.l; s.n; December 01, 1983. 6 p. tab. Abstract: Antigen and mitogen-induced gamma interferon (gamma-IFN) production was studied in peripheral blood mononuclear cells from 34 leprosy patients. 17 of 18 lepromatous leprosy and borderline lepromatous patients (LL and BL) failed to release gamma-IFN in response to specific antigen (Mycobacterium leprae) and displayed reduced responses to mitogen (concanavalin A) stimulation. In contrast, cells from six tuberculoid and borderline tuberculoid patients (TT and BT) produced considerable levels of gamma-IFN under the same experimental conditions. Normal controls failed to respond to M. leprae and most displayed good responses to concanavalin A. Mid-borderline patients (BB) showed intermediate levels of gamma-IFN release. gamma-IFN release by lepromatous patients could be partially restored with purified interleukin 2 and M. leprae antigen but not with interleukin 2 alone.(AU). Descriptors: HANSENIASE/imunol INTERFERON TIPO II/bios MYCOBACTERIUM LEPRAE/imunol ANTIGENOS DE BACTERIAS/imunol Limits: HUMANO SUPPORT, NON-U.S. GOV'T SUPPORT, U.S. GOV'T, P.H.S. Electronic Medium: http://www.ilsl.br Location: BR191.1; 01387/s

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Id: 13416 Author: Bjune, G Title: In vitro lymphocyte stimulation in leprosy; simultaneous stimulation with Mycobacterium leprae antigens and phytohaemagglutinin ..- Source: s.l; s.n; jun. 1979. 9 p. tab, graf. Abstract: Peripheral blood lymphocytes from 105 subjects with different forms of leprosy and healthy contacts of leprosy patients weere stimulated in vitro different preparations of mycobacterial antugens alone or in combination with a suboptimal dose of phytohaemagglutinin (PHA). In nearly all individuals sonicated leprosy bacilli and PHA together gave a lower 3H-thymidine incorporation than didi the same dose of PHA alone. There was no difference in the degree of inhibition seen in the different patient groups or the healthy contacts. High doses of whole, washed Mycobacterium leprae, combined with PHA led to an increased thymidine incorporation in borderline tuberculoid leprosy patients who had experienced a reversal reaction, and in healthy contacts with less than 6 months exposure did not show an augmentation of the PHA-induced thymidine incorporation. The inhibition exerted by sonicated M. leprae was dose-dependent, seen even with very low doses of antigen, and was not due to direct Cytotoxicity, M. bovis, strain BCG, was weakly suppressive effect. There was no correlation between the suppressive effective of M. leprae antigens and the other mtcobacteria neither was there any correlation with the responses to the mycobacterial antigens alone. Many lepromatous leprosy patients showed significant suppression of background incorporation with addition of M. leprae antigens. This paper discusses wheter the apparent `non-responsiveness` in lepromatous leprosy could be due to active suppressor mechanisms operative in vitro.(AU). Descriptors: ANTIGENOS DE BACTERIAS/imunol ANTIGENOS DE SUPERFÍCIE/imunol HANSENIASE/imunol HANSENIASE/metab TRANSFORMACAO LINFOCITICA TIMIDINA/metab FITOHEMAGLUTININAS/farmacol MYCOBACTERIUM LEPRAE/imunol RELACAO DOSE-RESPOSTA IMUNOLOGICA LINFOCITOS/metab Limits: HUMANO Electronic Medium: http://www.ilsl.br Location: BR191.1; 00020/s

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Id: 13414 Author: Closs, O; Kronvall, G Title: Experimental murine leprosy ..- Source: s.l; s.n; 1975. 6 p. ilus, tab. Abstract: Sera from C3H and C57BL mice infected with Mycobacterium lepraemurium (MLM) and from human leprosy patients were examined for antibodies against MLM by a crossed immunoelectrophoresis (CIE) technique. Altogether antibodies against six or seven MLM antigens were found in the mouse sera. After a small inoculum of MLM, C3H mice produced more antibodies than C57BL mice. After a large inoculum both strains produced about the same amount of antibodies but showed qualitative differences in their response patterns. A serum pool from patients with lepromatous leprosy contained antibodies against six MLM antigens; five of these were identical with the antigens against which antibodies were found in infected mice. C57BL mice that had lost their delayed-type hypersensitivity to MLM during the course of a disseminated infection showed a fairly strong antibody response to three antigens and a weak response to three others. Since almost the same spectrum of antibodies, although in lower titres, could be demonstrated in C57BL mice with intact delayed-type hypersensitivity to the bacilli, these antibodies did not seem to interfere with the expression of cell-mediated immunity.(AU). Descriptors: MODELOS ANIMAIS DE DOENCAS ANTIGENOS DE BACTERIAS ANTICORPOS ANTIBACTERIAS HIPERSENSIBILIDADE TARDIA/imunol IMUNIDADE CELULAR IMUNOELETROFORESE BIDIMENSIONAL HANSENIASE/imunol CAMUNDONGOS ENDOGÂMICOS C3H/imunol CAMUNDONGOS ENDOGÂMICOS C57BL/imunol MYCOBACTERIUM LEPRAEMURIUM/imunol Limits: HUMANO ANIMAL FEMININO CAMUNDONGOS Electronic Medium: http://www.ilsl.br Location: BR191.1; 00024/s

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Id: 13413 Author: Closs, O; Mshana, R. N; Harboe, M Title: Antigenic analysis of Mycobacterium leprae ..- Source: s.l; s.n; mar. 1979. 6 p. ilus. Abstract: About twenty distinct antigenic components have been demonstrated in Mycobacterium leprae (M. leprae) by crossed immunoelectrophoresis against a rabbit antiserum produced by immunization with concentrated M. leprae antigen. This system allows a more detailed analysis of the antigenic relationship between M. leprae and other mycobacteria and a better characterization of the antigenic content of various M leprae preparations than with previously available anstisera of the antigenic content of various M. leprae preparations than with previously available antisera which reacted with far fewer components. The antibody activity in sera of patients with lepromatous leprosy was studied by incorporating the sera into the intermediate gel of the M. leprae reference system. Antibodies were found against only seven of the components. Since those compared are all known to be cross-reacting widely with antigens of other mycobacteria, it is speculated that cross-immunization may influence the antibody response in lepromatous leprosy.(AU). Descriptors: IMUNOELETROFORESE BIDIMENSIONAL SOROTIPAGEM ANTIGENOS DE BACTERIAS/anal FRAGMENTOS DE IMUNOGLOBULINAS ANTICORPOS ANTIBACTERIAS MYCOBACTERIUM LEPRAE/imunol Limits: ANIMAL COELHOS Electronic Medium: http://www.ilsl.br Location: BR191.1; 00025/s

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Id: 13337 Author: Convit, J; Pinardi, M. E; Rodríguez Ochoa, G; Ulrich, M; Avila, J. L; Goihman M Title: Elimination of Mycobacterium leprae subsequent to local in vivo activation of macrophages in lepromatous leprosy by other mycobacteria ..- Source: s.l; s.n; jun. 1974. 5 p. ilus. Abstract: This investigation studied the possibility og activating lepromatous macrophages by a local `in vivo` test...(AU). Descriptors: VACINA BCG HANSENIASE/imunol HANSENIASE/patol LINFOCITOS/imunol ANTIGENOS DE BACTERIAS MACROFAGOS/imunol MYCOBACTERIUM BOVIS/imunol MYCOBACTERIUM LEPRAE/imunol MYCOBACTERIUM LEPRAEMURIUM/imunol DERMATOPATIAS/etiol - GRANULOMA/etnol  IMUNIDADE CELULAR  PELE/patol Limits: HUMANO Electronic Medium: http:/www.ilsl.br Location: BR191.1; 01063/s

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